The coronavirus pandemic transformed the world abruptly due to the speed of transmission and high morbidity and mortality. Many deaths have been quantified, and the scientific community intensifies the search for molecular targets, protein sequences and polymorphisms on SARS-CoV-2, to improve the clinical evolution and survival of patients. Initially, COVID-19 was described with respiratory changes, flu, and fever. With the spread of the disease, clinical manifestations were observed in other organ systems, still unknown. In this sense, the present study describes the main neurological changes and laboratory findings. The literature review was identified in the central databases: Scielo, Google Scholar, PubMed / MedLine, Embase, and Cochrane Database. Twenty-five articles related to the theme were chosen, including reviews, case series, cohort, and retrospective studies. Neurological manifestations were predominantly anosmia/hyposmia, dysgeusia, ataxia, and seizures. According to the latest published studies, attention must be paid to isolated initial neurological events.

COVID-19 disease is a pandemic, with severe clinical manifestations, high lethality and which has reached at least 128 countries. In this sense, the bioprotection of health professionals is a fundamental principle in preserving the lives of those who work in the direct care of patients who are victims of SARS-CoV-2. Each day the number of confirmed cases exceeds the most optimistic estimates, which cause severe damage and overload in the infrastructure of health systems. The present study addressed the main dilemmas and difficulties faced by health professionals in combating the pandemic. A literature review was carried out in the Embase, Scopus, Pubmed / Medline, Web of Science, Scielo, Cochrane Library, and Google Scholar databases, where 28 articles were selected after independent peer review. The most recent and relevant studies on the need for effective bioprotection were included. For this reason, we put the step by step for the reader to understand and execute. Besides, the indiscriminate use of personal protective equipment (PPE) was analyzed, what to do in the absence of such material, and the role of the professional as a health educator in the optimization of available resources. In conclusion, it is recommended to use PPE with parsimony and telehealth as a useful device in the emergency support of professionals working on the front lines in the fight against coronavirus.

Wound healing is a complex process with overlapping steps of haemostasis, the inflammatory and proliferative phases, remodelling .Any problem with the edge of the wound can be detrimental to healing and may cause delay in wound healing. In this article, we share our experience of using topical insulin therapy for wound bed preparation in non-healing ulcer over the amputation stump.

Skin metastases represent an infrequent secondary location of deep cancers. They represent 0.6 to 10% of metastases from solid tumors. We are reporting a case.